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KMID : 1123920020160061223
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 6 p.1223 ~ p.1229
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Immuno-Regulatory Effects of Cheongsimondam-tang
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Park Min-Chul
Jin Jae-Ho
Jeong Han-Sol
Lee Kwang-Gyu
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Abstract
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The purpose of this research was to investigate the effect of Cheongsimondam-tang(CSODT) on the activity of immune cell and anti-carcinogenic effect of mouse leukemia cell. The addition of CSODT(1 ㎍/ml) enhanced the proliferation of cultured-splenocytes and thymocytes. And also administration of CSODT(500 ㎍/kg) accelerated subpopulation of splenic and thymic T lymphocytes especially CD4/sup +/-T/sub H/ cells in BALB/c mice. CSODT treatment decreased cell proliferation and increased apoptotic cell death of cultured-L1210 leukemia cells, and induced apoptosis in addition to decreased mitochondrial transmembrane potential (ΔΨm) of transplanted-L1210 cells in vivo. These results suggest that CSODT have a cellular immuno-regulatory effect and anti-cancer property action.
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KEYWORD
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